With all of the controversy surrounding the Women’s Health Initiative (WHI), virtually all of the attention has been given to the 26,000 women in the placebo-controlled hormone trial. It is easy to forget that more than 68,000 women were enrolled in other overlapping clinical trials, and almost 160,000 women are being followed as part of an ongoing observational study.1 Here we will address the 2 completed nonhormone clinical trials.