Of the many unmet needs in the management of osteoporosis, perhaps the most fundamental is a general failure to identify patients at high risk for fracture who are likely to benefit from pharmacological intervention. To help identify patients at high risk for fracture, the National Osteoporosis Foundation (NOF) has developed comprehensive evidence-based clinical practice guidelines for the prevention and treatment of osteoporosis. An important component of the NOF guidelines is the use of the World Health Organization (WHO) Fracture Risk Assessment Tool (FRAX) to provide a 10-year probability of fracture.